Florence has enough educational opportunities to last for a lifetime of learning. Francis Marion University (FMU) consistently ranks among the Best Regional Universities by US News and World Report. For senior citizens, FMU also offers no-cost auditing of classes, depending on class size restrictions.

Florence-Darlington Technical College (FDTC) offers 2-year degrees and specialized trade courses.

On the FDTC campus is Southeastern Institute of Manufacturing and Technology (SiMT) which is focused on economic development through virtual / augmented reality, 3-D printing, and its social media listening center.