Stay.
Planning a trip to Florence, South Carolina? You’ll find welcoming places to rest and recharge—from trusted hotel brands to boutique inns and locally camping. Even better, most Florence area hotels are minutes from downtown dining, shopping, and attractions, so it’s easy to make the most of your stay.
Convenient Locations for Every Itinerary
If you want effortless access, choose lodging in our Hospitality District near I-95 and I-20; you’ll reach regional highways, road-trip routes, and nearby day trips in no time. However, travelers who prefer character and walkability should opt for historic Downtown Florence, where public art, live music, theaters, and chef-driven restaurants are steps away. Either choice keeps you close to everything.
Amenities That Add Comfort
Many properties include breakfast, complimentary Wi-Fi, fitness centers, and on-site parking. Additionally, a number of hotels are pet-friendly, so the whole family can come along.
Ideal for Business, Groups, and Getaways
Traveling with colleagues or a team? Numerous business-friendly hotels feature meeting rooms, group rates, and event services. Looking to escape? Couples planning a romantic weekend can choose a cozy suite or boutique inn with thoughtful, personal touches. Florence’s central location makes it easy to combine business with leisure—extend your stay and enjoy a night out downtown.
Why Book in Florence
Convenient locations, welcoming service, and abundant things to do make Florence, SC lodging a smart choice. Compare amenities, map nearby restaurants and attractions, and reserve the perfect room that fits your budget and itinerary. Finally, don’t forget to check pet policies, parking details, and seasonal deals before you book.
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🛎️ Major hotels, boutique inns, and B&Bs
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🚗 Quick access from I-95 and I-20
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🐾 Pet-friendly and family-ready options
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📍 Steps from Downtown Florence dining and entertainment
Stay Places to Explore in Coward, SC
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Stay, Campground / Rv Park, Play, Outdoors, Bike Trails, Walking Trails, Kayaking, Parks, Kid Friendly, Sports Facilities, Event Venues, Meeting Space, Wedding Venues, Rv Park, Campground, Lodging, Unique Experience Stays, Equestrian Trails, Sports Venues, Coward | 5094 County Park Rd, Coward, SC 29530, USA
Lynches River County Park
Discover Lynches River County ParkTravel just outside the city of Florence to explore Lynches River County Park, a 676-acre outdoor destination located along the historic Lynche...
Explore placeStay, Bed & Breakfast, Meeting Space | 111 Kuker St, Florence, SC 29501, USA
Ambrias Garden Manor
Ambrias Garden Manor was built in 1920. It is known locally as the Old Holman's House. The home was build by Francis P. Holman and was occupied by his family for the last eighty...
Explore placeFarm, Stay, Farmstay, Lodging, Unique Experience Stays | 603 N Sally Hill Rd, Timmonsville, SC 29161, USA
Dream Acres
Welcome to Dream Acres, a charming oasis where relaxation and tranquility come together in perfect harmony. Here, you will find a picturesque landscape filled with lush greenery...
Explore placeStay, Campground / Rv Park | 2115 2nd Loop Rd, Florence, SC 29501, USA
Second Loop Mobile Park LLC
Welcome to Second Loop Mobile Park LLC, a tranquil retreat where comfort meets the beauty of nature! This inviting mobile park is designed for those seeking a peaceful escape wi...
Explore placeStay, Exit 160, Hospitality District, Hotel, Pet-friendly, Meeting Space, Lodging, Event Venues, Meeting Space, Ball Room | 150 Westpark Dr, Florence, SC 29501, USA
Staybridge Suites Florence - Center by IHG
Conveniently located, we are easily accessible for guests attending events at the Florence Center, visiting our Veterans Park or in Florence for business at nearby GE Healthcare...
Explore placeStay, Campground / Rv Park, Lake City Accommodations | 243 S Church St, Lake City, SC 29560, USA
CrossRoads Coach Resort at the ROB
CrossRoads Coach Resort at the ROB is a quaint little RV park located in the Heart of Art! We offer paved streets and level concrete pads with ample room for slides. All sites h...
Explore placeStay, Boutique Hotels, Lake City Accommodations, Meeting Space | 128 W Main St, Lake City, SC 29560, USA
Inn at the Crossroads
Welcome to the Inn at the Crossroads, a charming haven that promises to envelop you in warmth and hospitality. Nestled at the heart of our vibrant community, this inviting lodge...
Explore placeStay, Exit 160, Hospitality District, Hotel, Lodging, Event Venues, Meeting Space | 3440 W Radio Dr, Florence, SC 29501, USA
Holiday Inn Express & Suites Florence I-95 & I-20 Civic Ctr by IHG
Welcome to the Holiday Inn Express & Suites Florence I-95 & I-20 Civic Center, where comfort meets convenience in the heart of Florence, South Carolina! Located at 3440...
Explore placeLodging, Stay, Exit 160, Hotel, Hospitality District, Pet-friendly, Event Venues, Meeting Space | 3000 W Radio Dr, Florence, SC 29501, USA
Hampton Inn & Suites Florence Center
Welcome to the Hampton Inn & Suites Florence Center, your ideal getaway in the heart of Florence, South Carolina! Conveniently located at 3000 W Radio Dr, our hotel offers e...
Explore placeStay, Boutique Hotels, Downtown Stays, Hotel, Premiere Stays | 126 W Evans St, Florence, SC 29501, USA
Hotel Florence, Tapestry Collection by Hilton
Welcome to Hotel Florence, Tapestry Collection by Hilton, a dazzling destination located at 126 W Evans St in the heart of Florence, South Carolina. This boutique hotel combines...
Explore placeStay, Exit 160, Hospitality District, Hotel, Lodging | 501 Woody Jones Blvd, Florence, SC 29501, USA
Fairfield by Marriott Inn & Suites Florence I-20
Welcome to the Fairfield by Marriott Inn & Suites Florence I-20, your perfect home away from home conveniently located at 501 Woody Jones Blvd, Florence, SC. Situated just o...
Explore placeStay, Exit 160, Hotel, Hospitality District, Pet-friendly, Exit 164, Event Venues, Meeting Space | 527 Woody Jones Blvd, Florence, SC 29501, USA
Comfort Inn & Suites Florence Center Area
Welcome to Comfort Inn & Suites Florence Center Area, your premier destination for comfort and convenience in the heart of Florence, South Carolina. Nestled at 527 Woody Jon...
Explore placeStay, Exit 164, Hotel, Lodging, Pet-friendly, Event Venues, Meeting Space, Ball Room | 1735 Stokes Rd, Florence, SC 29501, USA
Hampton Inn & Suites Florence-North-I-95
Welcome to the Hampton Inn & Suites Florence-North-I-95, the perfect getaway for travelers seeking comfort and convenience in the heart of Florence, South Carolina. Located...
Explore placeStay, Exit 160, Hospitality District, Hotel, Lodging, Pet-friendly, Premiere Stays | 2671 Hospitality Blvd, Florence, SC 29501, USA
Hilton Garden Inn Florence
Welcome to the Hilton Garden Inn Florence, where hospitality meets comfort. Located conveniently at 2671 Hospitality Blvd in Florence, South Carolina, our hotel is the perfect c...
Explore placeLodging, Stay, Exit 170, Hotel | 2101 Florence Harllee Blvd, SC-327, Florence, SC 29506, USA
Holiday Inn Express & Suites Florence I-95 @ Hwy 327 by IHG
Welcome to the Holiday Inn Express & Suites Florence I-95 @ Hwy 327 by IHG, where comfort and convenience come together to provide you with a delightful stay! Our friendly staff...
Explore placeStay, Exit 160, Hospitality District, Hotel, Pet-friendly, Event Venues, Meeting Space, Lodging | 2650 Hospitality Blvd, Florence, SC 29501, USA
TownePlace Suites by Marriott Florence
Welcome to TownePlace Suites by Marriott Florence, your home away from home in the heart of Florence, South Carolina! Located at 2650 Hospitality Blvd, our hotel provides the pe...
Explore placeStay, Downtown Stays, Hotel, Pet-friendly, Lodging, Event Venues, Meeting Space, Ball Room | 100 E Evans St, Florence, SC 29506, USA
Hyatt Place Florence / Downtown
Situated in the heart of Florence, South Carolina, Hyatt Place Florence/Downtown is your perfect gateway to experiencing the vibrant culture and hospitality that the city has to...
Explore placeStay, Exit 160, Hospitality District, Hotel, Extended Stay | 530 Woody Jones Blvd, Florence, SC 29501, USA
Affordable Suites Florence
Welcome to Affordable Suites Florence, your ideal home away from home nestled in the heart of Florence, SC. Located at 530 Woody Jones Blvd, our suites are surrounded by the cha...
Explore placeStay, Exit 164, Hotel, Lodging | 2038 W Lucas St, Florence, SC 29501, USA
Howard Johnson by Wyndham Florence
Welcome to Howard Johnson by Wyndham Florence, your premier destination for comfort and convenience in Florence, South Carolina. Nestled conveniently at 2038 W Lucas St, this we...
Explore placeLodging, Stay, Exit 164, Hotel, Pet-friendly | 2120 W Lucas St, Florence, SC 29501, USA
Comfort Suites Florence I-95
Welcome to Comfort Suites Florence I-95, your ideal getaway nestled in the heart of Florence, South Carolina. Conveniently located at 2120 W Lucas St, our hotel is strategically...
Explore placeStay, Exit 160, Hospitality District, Hotel, Pet-friendly, Lodging, Event Venues, Meeting Space | 2660 Hospitality Blvd, Florence, SC 29501, USA
Residence Inn by Marriott Florence
Welcome to the Residence Inn by Marriott Florence, an inviting home away from home located at 2660 Hospitality Blvd, Florence, SC 29501. This exceptional hotel seamlessly combin...
Explore placeCampground / Rv Park, Exit 157, Stay | 1600 Gateway Rd, Florence, SC 29501, USA
Swamp Fox Campground
Welcome to Swamp Fox Campground, a haven for nature lovers and adventure seekers alike! Nestled in the great outdoors, our campground invites you to relax and reconnect with nat...
Explore placeStay, Exit 160, Hospitality District, Hotel, Pet-friendly, Lodging | 3450 W Radio Dr, Florence, SC 29501, USA
Homewood Suites by Hilton Florence
Welcome to Homewood Suites by Hilton Florence, your ideal home away from home in the heart of Florence, South Carolina! Conveniently located at 3450 W Radio Dr, our all-suite ho...
Explore placeStay, Hotel, Lake City Accommodations | 319 Sumter St, Lake City, SC 29560, USA
Security Inn & Suites
Welcome to Security Inn & Suites, your premier destination for comfort and convenience located at 319 Sumter St, Lake City, SC 29560. Nestled in the heart of scenic Lake Cit...
Explore placeStay, Exit 160, Hospitality District, Hotel, Pet-friendly, Lodging | 900 Woody Jones Blvd, Florence, SC 29501, USA
Home2 Suites by Hilton Florence, SC
Welcome to Home2 Suites by Hilton Florence, SC, your ideal home away from home nestled in the heart of Florence! Strategically located at 900 Woody Jones Blvd, this modern all-s...
Explore placeStay, Exit 160, Hospitality District, Hotel, Lodging, Event Venues, Meeting Space | 2670 Hospitality Blvd, Florence, SC 29501, USA
SpringHill Suites by Marriott Florence
Welcome to SpringHill Suites by Marriott Florence, your premier destination for an unforgettable stay in the heart of Florence, SC. Conveniently located at 2670 Hospitality Blvd...
Explore placeStay, Exit 164, Hotel, Pet-friendly, Lodging | 1729 Mandeville Rd, Florence, SC 29501, USA
Park Inn by Radisson Florence, SC
Welcome to Park Inn by Radisson Florence, SC, your ideal haven for relaxation and comfort in the heart of Florence! Conveniently located at 1729 Mandeville Rd, our hotel is desi...
Explore placeStay, Exit 164, Hotel, Pet-friendly, Lodging | 2140 W Lucas St, Florence, SC 29501, USA
Tru by Hilton Florence I-95
Welcome to Tru by Hilton Florence I-95, your ideal sanctuary in the heart of Florence, South Carolina! Nestled conveniently off Interstate 95, our hotel offers a modern and vibr...
Explore placeCampground, Rv Park, Lodging, Stay, Campground / Rv Park | 1115 E Campground Rd, Florence, SC 29506, USA
Florence RV Park
Welcome to Florence RV Park, your ultimate getaway in nature! Nestled away from the hustle and bustle, our park offers you a peaceful retreat where the great outdoors meets comf...
Explore placeStay, Exit 164, Hotel, Pet-friendly, Lodging, Event Venues, Meeting Space | 2123 W Lucas St, Florence, SC 29501, USA
La Quinta Inn & Suites by Wyndham Florence
Welcome to La Quinta Inn & Suites by Wyndham Florence, your home away from home in the heart of Florence, South Carolina. Conveniently located at 2123 W Lucas St, our hotel...
Explore placeStay, Lodging, Exit 164, Hotel | 1808 W Lucas St, Florence, SC 29501, USA
Best Western Inn
Welcome to Best Western Inn, your home away from home located at 1808 W Lucas St in the charming city of Florence, South Carolina. Whether you're passing through or seeking a re...
Explore placeStay, Exit 160, Hospitality District, Hotel, Lodging, Pet-friendly | 2680 Hospitality Blvd, Florence, SC 29501, USA
Courtyard by Marriott Florence
Welcome to Courtyard by Marriott Florence, your ideal escape in the heart of Florence, South Carolina! Conveniently located at 2680 Hospitality Blvd, this modern hotel combines...
Explore placeStay, Exit 160, Hospitality District, Hotel, Pet-friendly, Lodging, Event Venues, Meeting Space | 150 Dunbarton Dr, Florence, SC 29501, USA
Quality Inn & Suites Florence Civic Center
Welcome to the Quality Inn & Suites Civic Center, your ideal retreat located in the heart of Florence, South Carolina! Situated at 150 Dunbarton Drive, our hotel combines co...
Explore placeStay, Exit 164, Hotel, Lodging | 1833 Florence Park Dr I-95 & US 52, Florence, SC 29501, USA
Sleep Inn Florence North
Welcome to Sleep Inn Florence North, your ideal retreat nestled in the heart of Florence, South Carolina. Conveniently located at 1833 Florence Park Dr, just off I-95 and US 52,...
Explore placeLodging, Stay, Hospitality District, Exit 160, Pet-friendly, Hotel, Meeting Space, Premiere Stays | 820 Woody Jones Blvd, Florence, SC 29501, USA
Aloft by Marriott Florence
Welcome to Aloft by Marriott Florence, a premier hotel located at 820 Woody Jones Blvd in Florence, South Carolina! Your retreat awaits in this vibrant city, where contemporary...
Explore placeStay, Exit 160, Hospitality District, Hotel, Pet-friendly | 2690 David H McLeod Blvd, Florence, SC 29501, USA
Red Roof Inn Florence - Civic Center
Welcome to the Red Roof Inn Florence - Civic Center, your perfect home away from home in the heart of Florence, South Carolina! Conveniently situated at 2690 David H McLeod Blvd...
Explore placeStay, Exit 164, Hotel, Pet-friendly | 1832 1/2 W Lucas St, Florence, SC 29501, USA
Super 8 by Wyndham Florence
Welcome to Super 8 by Wyndham Florence, your home away from home! With comfortable accommodations, friendly staff, and a host of amenities, your stay will be nothing short of de...
Explore placeStay, Lake City Accommodations, Hotel, Pet-friendly | 170 S Ron McNair Blvd, Lake City, SC 29560, USA
Days Inn by Wyndham Lake City
Welcome to Days Inn by Wyndham Lake City, your perfect retreat nestled in the heart of South Carolina! Conveniently located at 170 S Ron McNair Blvd, our hotel offers a cozy and...
Explore placeStay, Lodging, Exit 164, Pet-friendly, Hotel | 1739 Mandeville Rd, Florence, SC 29501, USA
Spark by Hilton Florence North I-95, SC
Welcome to Spark by Hilton Florence North I-95, your ultimate getaway nestled in the heart of Florence, South Carolina. Conveniently located at 1739 Mandeville Rd, this modern h...
Explore placeStay, Exit 164, Hotel, Pet-friendly | 2111 W Lucas St, Florence, SC 29501, USA
Days Inn by Wyndham Florence/I-95 North
Welcome to Days Inn by Wyndham Florence/I-95 North, your comfortable retreat while traveling! Conveniently located and thoughtfully designed, our hotel offers all the amenities...
Explore placeStay, Exit 160, Hospitality District, Hotel, Pet-friendly, Meeting Space | 140 Dunbarton Dr, Florence, SC 29501, USA
Days Inn by Wyndham Florence Near Civic Center
Welcome to Days Inn by Wyndham Florence Near Civic Center, where comfort and hospitality await you! Conveniently situated and designed for relaxation, our hotel is the perfect s...
Explore placeStay, Hotel, Lake City Accommodations | 202 N Ron McNair Blvd, Lake City, SC 29560, USA
Quality Inn & Suites Lake City
Welcome to Quality Inn & Suites Lake City, where quality meets comfort! Our inviting hotel is designed to make you feel at home, equipped with modern amenities and a friendly st...
Explore placeStay, Exit 164, Meeting Space, Hotel | 1912 Enterprise Dr, Florence, SC 29501, USA
Microtel Inn & Suites by Wyndham Florence
Welcome to Microtel Inn & Suites by Wyndham Florence, where comfort and hospitality meet! Our inviting hotel is the perfect place to unwind, whether you're traveling for busines...
Explore placeExit 157, Meeting Space, Pet-friendly, Hotel | 3821 Bancroft Rd, Florence, SC 29501, USA
Florence Inn and Suites
Welcome to Florence Inn and Suites, your cozy retreat nestled in the heart of Florence! Designed with your comfort in mind, our well-appointed guest rooms offer a serene escape...
Explore placeStay, Exit 164, Hotel, Pet-friendly, Meeting Space | 1920 W Lucas St, Florence, SC 29501, USA
Econo Lodge Florence - Darlington
Welcome to Econo Lodge Florence - Darlington, your home away from home! We are thrilled to offer you a comfortable and affordable stay, perfect for travelers looking to explore...
Explore placeStay, Exit 164, Hotel, Pet-friendly, Meeting Space | 1819 W Lucas St Bldg B, Florence, SC 29501, USA
MainStay Suites Florence - Darlington
Welcome to MainStay Suites Florence - Darlington, your home away from home! Nestled in the picturesque city of Florence, this cozy and inviting hotel offers a delightful blend o...
Explore placeStay, Exit 164, Hotel, Pet-friendly, Extended Stay | 1914 W Lucas St I-95 & US 52, Florence, SC 29501, USA
Suburban Studios Florence I-95
Welcome to Suburban Studios Florence I-95, where convenience and comfort meet! This charming extended-stay hotel is designed for travelers seeking relaxation with all the essent...
Explore placeStay, Exit 164, Hotel, Pet-friendly | 2004 W Lucas St, Florence, SC 29501, USA
Motel 6 Florence, SC
Welcome to Motel 6 Florence, SC, where comfort and affordability await! As you step in, you'll find a friendly atmosphere ready to make you feel right at home. Whether you’re pa...
Explore placeStay, Exit 164, Hotel, Pet-friendly, Meeting Space | 1819 W Lucas St Bldg A, Florence, SC 29501, USA
Clarion Inn & Suites Florence - Darlington
Welcome to Clarion Inn & Suites Florence - Darlington, where comfort meets southern hospitality! This charming hotel is designed with your relaxation in mind, offering spacious...
Explore placeStay, Lodging, Exit 170, Hotel | 2111 Florence Harllee Blvd, Florence, SC 29506, USA
Hilton Garden Inn Florence North I-95
*Opening September 2026*We’re located just three miles from golf at the Country Club of South Carolina. Florence Downtown Historic District and Florence Regional Airport – FLO a...
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